P.I. and Program Director

George Macones, MD, MSCE
, principal investigator for the Washington University WRHR Career Development Program, is the Mitchell and Elaine Yanow Professor and Head of the Department of Obstetrics and Gynecology. In addition to directing a T32 in reproductive epidemiology at the University of Pennsylvania, Macones has been or is principal investigator for a number of NIH grants focused on reproductive epidemiologic studies. Macones has completed a large retrospective cohort study/nested case-control study to investigate the incidence and risk factors for uterine rupture among women attempting a vaginal birth after cesarean section. This project has resulted in more than 25 peer-reviewed publications. Macones was the PI on an NIH-funded, multicenter, randomized clinical trial to test indomethacin as a tocolytic agent. He is also PI of an R01 for a prospective assessment to develop a predictive index for a successful trial of labor among women with a prior cesarean delivery (data analysis underway). Macones was awarded a grant from the Commonwealth of Pennsylvania Department of Health to develop a Center of Excellence for Research on Pregnancy Outcomes. Macones still serves as PI for this center, and the primary study funded through this center is a multicenter RCT to test whether screening and treating periodontal disease in pregnancy can reduce the occurrence of spontaneous preterm birth. Lastly, Macones is also the PI of a R01 from the National Cancer Institute to assess the relationship between LEEP and preterm birth.

Macones has received national and international recognition for his research, including best oral presentation in the first plenary session at the Society of Maternal-Fetal Medicine in 2001 and best international research at the Japanese Society of Obstetrics and Gynecology. Macones has served as an ad hoc reviewer for a variety of NIH/NICHD study sections and is currently a chartered member of the Infectious Disease, Reproductive Health, Asthma, and Pulmonary Conditions (IRAP) study section at the NIH Center for Scientific Review. He serves on the international editorial board for BJOG: An International Journal of Obstetrics and Gynaecology and is currently associate editor for AJOG: American Journal of Obstetrics & Gynecology. Macones has also served as a member of the Food and Drug Administration’s Advisory Committee on Reproductive Health Drugs. He currently serves on the board of directors of the Society for Maternal-Fetal Medicine and is a member of the program committee for that Society’s annual meeting. Most recently, Macones was elected to the American Society of Clinical Investigation.

Kelle H. Moley, MD, is the program director for the Washington University School of Medicine WRHR Career Development Program. Moley is the James P. Crane Professor of Obstetrics and Gynecology and vice chair for basic research. She is also director of the Division of Basic Science Research in the Department of Obstetrics and Gynecology at Washington University. She is an international expert in the field of glucose transporter biology and highly regarded for her work in preimplantation embryogenesis and implantation in mammalian models of maternal metabolic diseases. She has been continuously funded by NIH RO1s since 1999 and has published more than 85 manuscripts in high-impact, peer-reviewed basic science and translational science journals. She is vice chair of the Department of Obstetrics and Gynecology, director of the Division of Basic Science Research, and board certified in obstetrics and gynecology and reproductive endocrinology and infertility.
Moley serves in key leadership roles both at the university and nationally. She is an active member of the Society for Gynecologic Investigation (program chair 2007, council member 2008-11), the Society for the Study of Reproduction (chair of the Clinical Outreach Committee), the Society of Reproductive Endocrinology and Infertility (representative to the American Board of Obstetrics and Gynecology), serves as co-chair of the Selection Committee of the Reproductive Scientist Development Program, and is one of six associate editors of the American Journal of Physiology–Endocrinology and Metabolism. Moley also serves as fellowship director of the Reproductive Endocrinology and Infertility Fellowship Program at Washington University. Moley serves as co-PI on a T32 in reproductive sciences held by the Department of Obstetrics and Gynecology. Moley is also on the steering committee of the Markey Pathway for biomedical training of doctoral students and serves as director of the Clinical Mentorship Program. Recently, she was elected to the American Society of Clinical Investigation.